Solider pseudopapillärer tumor

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By Virginia Kneeland Frantz, M.D., Professor of Surgery, College of Physicians and Surgeons, Columbia University. MR Imaging Features of Small Solid Pseudopapillary Tumors: Retrospective Differentiation From Other Small Solid Pancreatic Tumors.

solider pseudopapillärer tumor

Br J Radiol. Am J Clin Pathol. Washington, D.C.: Armed Forces Institute of Pathology. J Korean Soc Radiol. These stains help pathologists confirm the diagnosis and rule out other tumours.

For solid pseudopapillary neoplasms, the tumour cells usually show:

  • Strong staining for β-catenin is seen in the nucleus and cytoplasm of the cells.
  • Positive results for proteins such as cyclin D1, vimentin, and CD10.
  • The absence of specific proteins, such as chromogranin A and trypsin, helps distinguish this type of pancreatic tumour from others.

These tests are important because other tumours, like neuroendocrine tumours or acinar cell carcinomas, can look similar under the microscope.

Perineural invasion

Perineural invasion occurs when cancer cells are found inside or around nerves.

doi:10.1245/aso.2002.9.1.35 - Pubmed

  • 3. Solid Pseudopapillary Neoplasm of the Pancreas with Elevated β-HCG Levels: A Case Report. AJR Am J Roentgenol. Insights Imaging. Omiyale A. Solid Pseudopapillary Neoplasm of the Pancreas. World J Hepatol. Journal of British Surgery. AJR Am J Roentgenol. doi:10.1007/s10238-025-01733-9 - Pubmed

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    Related articles: Pathology: Hepato-Pancreato-Biliary

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    Solid-pseudopapilläre Neoplasien (SPN)

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    Solid-pseudopapilläre Neoplasien sind häufig Zufallsbefunde.

    Yu M, Lee J, Kim M et al. 1959;47(203):334. Makroskopisch zeigt sich typischerweise ein randständig solides und zentral hämorrhagisch zerfallenes Gewebe. Humphreys G. In Memoriam. doi:10.1007/s13244-011-0102-7 - Pubmed

  • 11. The result is that the tumour cells do not adhere tightly, a characteristic feature of this tumour.
  • Developmental origin: Tumours similar to solid pseudopapillary neoplasms have been found in the ovary and testis, suggesting that the cells that form this tumour may initially come from structures called genital ridges.